The Mitochondrial TOM Complex Is Required for tBid/Bax-induced Cytochrome c Release
نویسندگان
چکیده
منابع مشابه
The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release.
Cytochrome c release from mitochondria is a key event in apoptosis signaling that is regulated by Bcl-2 family proteins. Cleavage of the BH3-only protein Bid by multiple proteases leads to the formation of truncated Bid (tBid), which, in turn, promotes the oligomerization/insertion of Bax into the mitochondrial outer membrane and the resultant release of proteins residing in the intermembrane s...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m703155200